/* BioTwin R2: substantive science, research, media and ecosystem components. */
.r2-evidence-heading {display:flex;align-items:end;justify-content:space-between;gap:32px;margin-bottom:38px}
.r2-evidence-heading h2 {margin-bottom:0}
.r2-evidence-heading>.text-link {flex-shrink:0}
.r2-science-feature {display:grid;grid-template-columns:1.2fr 1fr;gap:clamp(32px,5vw,90px);align-items:center;margin-top:42px}
.r2-science-feature figure {margin:0;border-radius:24px;overflow:hidden;background:#e8eeef}
.r2-science-feature img {display:block;width:100%;height:540px;object-fit:cover}
.r2-science-feature h3 {font-size:clamp(34px,3.6vw,56px);line-height:1.06;letter-spacing:-.04em;margin:16px 0 26px;font-weight:500}
.r2-science-feature p:not(.duo-eyebrow) {max-width:480px;line-height:1.7;color:#53646a;margin-bottom:26px}
.r2-medical-intro {display:grid;grid-template-columns:1.2fr 1fr;gap:clamp(24px,5vw,80px);align-items:end;margin:72px 0 30px;padding-top:42px;border-top:1px solid #d4e0e0}
.r2-medical-intro h3 {font-size:clamp(30px,3vw,46px);font-weight:500;line-height:1.1;letter-spacing:-.04em;margin:0}
.r2-medical-intro>p {font-size:17px;line-height:1.65;color:#53676d;margin:0;max-width:520px}
.r2-scope-domains {display:flex;gap:10px;flex-wrap:wrap}
.r2-scope-domains span {padding:10px 15px;border:1px solid #d5e1df;border-radius:30px;font-size:13px;color:#355b60}
.r2-scope-domains span:first-child {background:#153f42;color:#fff;border-color:#153f42}
.r2-scope-banner {display:grid;grid-template-columns:1.1fr 1fr;gap:50px;align-items:center;margin:36px auto 0;max-width:1280px;width:calc(100% - 96px);padding:44px;background:#edf3f1;border:1px solid #dae4e0;border-radius:22px}
.r2-scope-banner h2 {font-size:clamp(28px,3vw,44px);font-weight:500;line-height:1.1;letter-spacing:-.035em;margin:0}
.r2-scope-banner>div>p:not(.duo-eyebrow) {color:#4e686c;line-height:1.65;margin:0 0 20px}
.r2-medical-grid {display:grid;grid-template-columns:1.1fr 1fr 1fr;gap:18px;margin-top:34px}
.r2-medical-domain {background:#f2f6f5;border:1px solid #d9e4e2;border-radius:18px;padding:28px}
.r2-medical-domain-oncology {grid-row:span 2;background:#153f42;color:#fff;border-color:#153f42}
.r2-medical-domain h3 {font-size:26px;font-weight:500;line-height:1.12;letter-spacing:-.025em;margin:0 0 18px}
.r2-medical-domain>p {font-size:13px;margin:-6px 0 26px;color:#c0ded8}
.r2-medical-domain .r2-evidence-index {margin-bottom:20px}
.r2-medical-domain-oncology .r2-evidence-index {color:#a6cfc8}
.r2-medical-domain ul {list-style:none;padding:0;margin:0;display:grid;gap:10px}
.r2-medical-domain li {font-size:15px;line-height:1.45;padding-top:10px;border-top:1px solid #d9e3e1}
.r2-medical-domain-oncology li {font-size:18px;border-color:#ffffff2b;color:#ecf6f3;padding:14px 0 6px}
.r2-evidence-footer>.r2-source-note {margin:0!important}
.r2-evidence-logos {display:grid;grid-template-columns:repeat(6,minmax(0,1fr));gap:14px}
.r2-evidence-logo {background:#fff;border:1px solid #dde5e5;border-radius:14px;min-height:140px;padding:24px 18px 18px;display:flex;flex-direction:column;justify-content:center;align-items:center;gap:18px;text-align:center}
.r2-evidence-logo img {width:100%;height:57px;object-fit:contain;max-width:165px}
.r2-evidence-logo span {font-size:11px;line-height:1.35;color:#5e6a6b;max-width:160px}
.r2-logo-group {margin-top:40px}
.r2-logo-group>h3 {font-size:18px;font-weight:500;margin-bottom:18px}
.r2-logo-group .r2-evidence-logos {grid-template-columns:repeat(5,minmax(0,1fr))}
.r2-logo-group:first-of-type .r2-evidence-logos {grid-template-columns:repeat(6,minmax(0,1fr))}
.r2-media-cards {display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:24px}
.r2-media-card {display:block;color:inherit;text-decoration:none;border:1px solid #dae2e3;border-radius:18px;overflow:hidden;background:#fff;transition:transform .2s,box-shadow .2s}
.r2-media-card:hover {transform:translateY(-4px);box-shadow:0 16px 34px #18393912}
.r2-media-image {position:relative;aspect-ratio:16/9;background:#d5dddd;overflow:hidden}
.r2-media-image img {width:100%;height:100%;object-fit:cover;display:block}
.r2-media-play {position:absolute;inset:auto 16px 16px auto;width:44px;height:44px;background:#ffffffee;border-radius:50%;display:grid;place-items:center;color:#183738;font-size:22px}
.r2-media-card>div:last-child {padding:26px}
.r2-media-card h3 {font-weight:500;font-size:24px;line-height:1.2;letter-spacing:-.025em;min-height:3.6em;margin:12px 0 22px}
.r2-media-card .duo-eyebrow {font-size:11px;letter-spacing:.08em}
.r2-media-action {display:flex;align-items:center;justify-content:space-between;font-size:14px;font-weight:600}
.r2-media-action b,.r2-media-library-grid b {font-weight:400}
.r2-media-names {display:flex;flex-wrap:wrap;justify-content:center;align-items:center;gap:24px 48px;margin-top:34px;padding-top:28px;border-top:1px solid #dbe3e4}
.r2-media-name {color:#263c42;font-size:20px;font-weight:600;letter-spacing:-.03em;text-decoration:none}
.r2-media-name span {font-size:14px;font-weight:400}
.r2-pipeline-steps {display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:20px;margin-top:36px}
.r2-pipeline-steps article {padding:30px;background:#edf2f1;border-radius:18px}
.r2-evidence-index {display:block;font-size:13px;letter-spacing:.05em;color:#638184;margin-bottom:28px}
.r2-pipeline-steps h3 {font-size:28px;font-weight:500;letter-spacing:-.035em;line-height:1.15;margin:12px 0 18px}
.r2-pipeline-steps p:not(.duo-eyebrow) {font-size:16px;line-height:1.65;color:#4c646b}
.r2-evidence-footer {margin-top:32px;display:flex;justify-content:space-between;gap:24px;align-items:center;flex-wrap:wrap}
.r2-source-note {font-size:13px!important;line-height:1.6!important;color:#627277!important;margin-top:24px!important;max-width:960px}
.r2-source-note .text-link {font-size:inherit}
.r2-science-heading {padding-bottom:72px!important}
.r2-science-heading h1 {max-width:1150px}
.r2-science-heading>p:last-of-type {max-width:780px}
.r2-science-method-grid {display:grid;grid-template-columns:1fr 1fr;gap:clamp(28px,5vw,80px);align-items:stretch;margin-top:38px}
.r2-science-method-grid>img {display:block;width:100%;height:100%;min-height:500px;object-fit:cover;border-radius:22px}
.r2-science-method-grid ol {list-style:none;padding:0;margin:0}
.r2-science-method-grid li {display:flex;gap:24px;padding:24px 0;border-bottom:1px solid #d7e2e2}
.r2-science-method-grid li:first-child {padding-top:0}
.r2-science-method-grid li>span {color:#547e80;font-size:13px;padding-top:7px}
.r2-science-method-grid h3 {font-size:24px;font-weight:500;letter-spacing:-.03em;margin:0 0 10px}
.r2-science-method-grid li p {color:#52666b;font-size:16px;line-height:1.65;margin:0}
.r2-domain-grid {display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:24px;margin-top:40px}
.r2-domain-card {padding:36px;border-radius:20px;border:1px solid #d7e2e1;background:#f6f9f8;display:flex;flex-direction:column;align-items:start}
.r2-domain-card:first-child {background:#143b3e;color:#fff;border-color:#143b3e}
.r2-domain-card:first-child .duo-eyebrow,.r2-domain-card:first-child .r2-evidence-index {color:#b4dbd3}
.r2-domain-card h3 {font-weight:500;font-size:31px;line-height:1.13;letter-spacing:-.035em;margin:8px 0 22px;max-width:420px}
.r2-domain-card p:not(.duo-eyebrow) {font-size:16px;line-height:1.65;color:#51686d}
.r2-domain-card p.r2-domain-conditions {font-size:14px;font-weight:600;color:#345e61;margin:0 0 10px}
.r2-domain-card:first-child p:not(.duo-eyebrow) {color:#d1e4e2}
.r2-domain-card .text-link {margin-top:auto;padding-top:18px}
.r2-domain-card:first-child .text-link {color:#fff}
.r2-science-vision {display:grid;grid-template-columns:1fr 1fr;gap:clamp(32px,5vw,80px);align-items:center}
.r2-science-vision>img {width:100%;height:540px;object-fit:cover;border-radius:22px}
.r2-science-vision p:not(.duo-eyebrow) {font-size:18px;line-height:1.7;color:#52666b;max-width:540px}
.r2-science-vision .button {margin-top:18px}
.r2-evidence-details {border-top:1px solid #cfdcdd;margin-top:36px}
.r2-evidence-details details {border-bottom:1px solid #cfdcdd}
.r2-evidence-details summary {cursor:pointer;list-style:none;display:flex;align-items:center;justify-content:space-between;gap:24px;padding:26px 0}
.r2-evidence-details summary::-webkit-details-marker {display:none}
.r2-evidence-details summary b {display:block;font-size:21px;font-weight:500;letter-spacing:-.02em;line-height:1.3}
.r2-evidence-details summary small {display:block;font-size:13px;color:#62777b;margin-top:8px;line-height:1.5}
.r2-evidence-details summary>span:last-child {font-size:27px;font-weight:300;transition:transform .2s}
.r2-evidence-details details[open] summary>span:last-child {transform:rotate(45deg)}
.r2-evidence-details details>div {padding:0 48px 26px 0;max-width:920px}
.r2-evidence-details details>div p {font-size:16px;line-height:1.7;color:#52686e;margin:0 0 16px}
.r2-media-library-grid {display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:0 40px;margin-top:28px}
.r2-media-library-grid>a {padding:26px 0;border-bottom:1px solid #d1dddf;color:inherit;text-decoration:none}
.r2-media-library-grid h3 {font-size:22px;line-height:1.3;font-weight:500;letter-spacing:-.025em;margin:12px 0 18px}
.r2-media-library-grid>a>span:last-child {font-size:14px;font-weight:500;display:flex;justify-content:space-between}
.r2-evidence-details summary:focus-visible,.r2-media-card:focus-visible,.r2-media-library-grid>a:focus-visible {outline:3px solid #347e80;outline-offset:5px}
@media(max-width:900px){
 .r2-evidence-heading {align-items:start;flex-direction:column;gap:22px}
 .r2-evidence-logos,.r2-logo-group .r2-evidence-logos,.r2-logo-group:first-of-type .r2-evidence-logos {grid-template-columns:repeat(3,minmax(0,1fr))}
 .r2-science-feature {grid-template-columns:1fr 1fr;gap:28px}
 .r2-science-feature img {height:460px}
 .r2-media-card>div:last-child {padding:20px}
 .r2-media-card h3 {font-size:21px}
 .r2-pipeline-steps article {padding:24px}
 .r2-pipeline-steps h3 {font-size:24px}
 .r2-domain-card {padding:28px}
 .r2-medical-domain {padding:23px}
 .r2-medical-domain h3 {font-size:23px}
 .r2-science-method-grid>img {min-height:560px}
}
@media(max-width:640px){
 .r2-science-feature,.r2-science-method-grid,.r2-science-vision {grid-template-columns:1fr;gap:28px}
 .r2-medical-intro {grid-template-columns:1fr;gap:22px;margin-top:42px;padding-top:34px}
 .r2-scope-banner {grid-template-columns:1fr;gap:24px;width:calc(100% - 40px);padding:28px;margin-top:22px}
 .r2-medical-grid {grid-template-columns:1fr;gap:14px}
 .r2-medical-domain {padding:26px}
 .r2-medical-domain-oncology {grid-row:auto}
 .r2-medical-domain-oncology ul {grid-template-columns:1fr 1fr;gap:8px 20px}
 .r2-medical-domain-oncology li {font-size:16px}
 .r2-science-feature img,.r2-science-vision>img {height:auto;aspect-ratio:4/3;object-fit:cover}
 .r2-science-feature h3 {font-size:36px}
 .r2-evidence-logos,.r2-logo-group .r2-evidence-logos,.r2-logo-group:first-of-type .r2-evidence-logos {grid-template-columns:repeat(2,minmax(0,1fr));gap:10px}
 .r2-evidence-logo {padding:20px 14px;min-height:128px}
 .r2-evidence-logo img {height:48px}
 .r2-evidence-logo span {font-size:10px}
 .r2-media-cards,.r2-pipeline-steps,.r2-domain-grid,.r2-media-library-grid {grid-template-columns:1fr;gap:20px}
 .r2-media-card h3 {min-height:0;font-size:24px}
 .r2-media-names {gap:22px;justify-content:start}
 .r2-media-name {font-size:18px}
 .r2-pipeline-steps h3 {font-size:28px}
 .r2-pipeline-steps article {padding:28px}
 .r2-evidence-index {margin-bottom:22px}
 .r2-science-heading h1 {font-size:clamp(40px,10vw,64px)}
 .r2-science-method-grid>img {min-height:0;aspect-ratio:4/3}
 .r2-science-method-grid h3 {font-size:22px}
 .r2-domain-card {padding:28px}
 .r2-domain-card h3 {font-size:28px}
 .r2-science-vision>img {order:-1}
 .r2-evidence-details summary b {font-size:18px}
 .r2-evidence-details summary small {font-size:12px}
 .r2-evidence-details details>div {padding-right:0}
 .r2-media-library-grid {gap:0}
}
@media(prefers-reduced-motion:reduce){.r2-media-card,.r2-evidence-details summary>span:last-child {transition:none}}