Scientific publications, white papers, and technology insights from BioTwin - the research-grade virtual twin platform. BioTwin technology shown here is not authorized as a medical device.https://biotwin.aien-ushttps://biotwin.ai/blog/publications/fatigue-dbs-metabolomicshttps://biotwin.ai/blog/publications/fatigue-dbs-metabolomicsPreprint by Hauguel, Anctil, and Noel showing that dried blood spot metabolomics in 1,784 adults captures the same carnitine, TCA-cycle, redox-thiol, and tryptophan-kynurenine pathways previously implicated in ME/CFS plasma studies, scaling with symptom severity.Mon, 08 Jun 2026 00:00:00 GMTpublicationfatigueME/CFSmetabolomicsdried blood spotspreprintPierrick Hauguel, Nicolas Anctil, Louis-Philippe Noelhttps://biotwin.ai/blog/science-explained/how-wearables-and-biology-work-togetherhttps://biotwin.ai/blog/science-explained/how-wearables-and-biology-work-togetherWearables show what life looks like from the outside. Biology helps show what may be changing on the inside. BioTwin brings those two layers together.Wed, 06 May 2026 00:00:00 GMTscience-explainedplain languagewearablesbiologycontextintegrationBioTwin Editorial Teamhttps://biotwin.ai/blog/science-explained/me-vs-me-personal-baselinehttps://biotwin.ai/blog/science-explained/me-vs-me-personal-baselinePopulation averages can be useful, but they do not always capture what is normal for one individual. BioTwin is designed to understand change relative to your own baseline.Wed, 06 May 2026 00:00:00 GMTscience-explainedplain languagepersonal baselinelongitudinal datainterpretationBioTwin Editorial Teamhttps://biotwin.ai/blog/science-explained/what-30000-biomarkers-really-meanshttps://biotwin.ai/blog/science-explained/what-30000-biomarkers-really-meansBioTwin does not use the phrase 30,000+ biomarker-derived metabolic signals to sound impressive. It matters because deeper biological measurement creates a richer picture of what is happening inside the body.Wed, 06 May 2026 00:00:00 GMTscience-explainedplain languagebiomarkersmetabolomicsdeep measurementBioTwin Editorial Teamhttps://biotwin.ai/blog/science-explained/what-is-a-human-virtual-twinhttps://biotwin.ai/blog/science-explained/what-is-a-human-virtual-twinA simple explanation of what a human virtual twin is, why it matters, and how BioTwin uses biology, behavior, and time to build a more useful picture of health.Wed, 06 May 2026 00:00:00 GMTscience-explainedvirtual twinplain languageintroductionlongitudinal datametabolomicsBioTwin Editorial Teamhttps://biotwin.ai/blog/science-explained/what-your-virtual-twin-can-do-todayhttps://biotwin.ai/blog/science-explained/what-your-virtual-twin-can-do-todayBioTwin's virtual twin is designed to support clearer longitudinal health understanding today, while broader medical and clinical capabilities remain in development.Wed, 06 May 2026 00:00:00 GMTscience-explainedplain languagescopetrustwellnessresearchBioTwin Editorial Teamhttps://biotwin.ai/blog/science-explained/why-a-single-blood-test-is-not-enoughhttps://biotwin.ai/blog/science-explained/why-a-single-blood-test-is-not-enoughA one-time result can be helpful, but it cannot fully explain how your biology is changing. BioTwin is built around trajectories, not snapshots.Wed, 06 May 2026 00:00:00 GMTscience-explainedplain languagelongitudinal databiomarkerstrajectoriesBioTwin Editorial Teamhttps://biotwin.ai/blog/white-papers/medical-white-paperhttps://biotwin.ai/blog/white-papers/medical-white-paperScientific overview of BioTwin's medical research methodology, validation approach, and clinical development pathway.Wed, 06 May 2026 00:00:00 GMTwhite-paperwhite papermedicalmethodologyBioTwin Research Teamhttps://biotwin.ai/blog/white-papers/non-medical-white-paperhttps://biotwin.ai/blog/white-papers/non-medical-white-paperScientific overview of BioTwin's non-medical virtual twin technology, including longitudinal Bio-Signature tracking, personal baseline modeling, and wellness-only interpretation.Wed, 06 May 2026 00:00:00 GMTwhite-paperwhite papernon-medicalwellnessBioTwin Research Teamhttps://biotwin.ai/blog/why-we-built-a-human-virtual-twinhttps://biotwin.ai/blog/why-we-built-a-human-virtual-twinA blood test is a snapshot. A human body is a film. The founding idea behind BioTwin: a person should be understood as a trajectory, not a single measurement.Tue, 05 May 2026 00:00:00 GMTfounderfounder seriesvirtual twinlongitudinal datapreventive healthmetabolomicsPierrick Hauguelhttps://biotwin.ai/blog/chronic-fatigue-is-not-just-tirednesshttps://biotwin.ai/blog/chronic-fatigue-is-not-just-tirednessOne word covers too many biological realities. BioTwin's fatigue work treats fatigue as a measurable state space, not a single symptom.Mon, 04 May 2026 00:00:00 GMTfounderfounder seriesfatiguechronic fatiguewearablesrecoverylongitudinal dataPierrick Hauguelhttps://biotwin.ai/blog/what-cancer-prevention-still-misseshttps://biotwin.ai/blog/what-cancer-prevention-still-missesCancer prevention is personal before it is scientific. Why preventive health needs to move from isolated detection events to continuous biological context.Sun, 03 May 2026 00:00:00 GMTfounderfounder seriescancer preventionscreeningearly detectionpreventive medicinePierrick Hauguelhttps://biotwin.ai/blog/how-biology-detected-a-vegan-transitionhttps://biotwin.ai/blog/how-biology-detected-a-vegan-transitionA diet change is easy to declare and harder to verify. How longitudinal metabolomics shows what actually appeared in the body when the founder went vegan.Sat, 02 May 2026 00:00:00 GMTfounderfounder seriesnutritionveganmetabolomicsdiet responselongitudinal dataPierrick Hauguelhttps://biotwin.ai/blog/nutrition-fasting-supplements-biological-responsehttps://biotwin.ai/blog/nutrition-fasting-supplements-biological-responseThe body does not respond to intention. It responds to inputs. Why a virtual twin turns nutrition from a belief system into a learning system.Fri, 01 May 2026 00:00:00 GMTfounderfounder seriesnutritionfastingsupplementsmetabolomicspersonalized healthPierrick Hauguelhttps://biotwin.ai/blog/caffeine-alcohol-personal-responsehttps://biotwin.ai/blog/caffeine-alcohol-personal-responseThe body keeps receipts. Why caffeine and alcohol are personal pharmacology hiding inside everyday habits, and what longitudinal data reveals.Thu, 30 Apr 2026 00:00:00 GMTfounderfounder seriescaffeinealcoholrecoverywearablessleepPierrick Hauguelhttps://biotwin.ai/blog/how-travel-rewrites-your-biologyhttps://biotwin.ai/blog/how-travel-rewrites-your-biologyA flight is not one event in the body. It is a sequence. Your itinerary says when you arrived. Your biology says when you recovered.Wed, 29 Apr 2026 00:00:00 GMTfounderfounder seriestraveljet lagcircadianrecoverywearablesPierrick Hauguelhttps://biotwin.ai/blog/six-connected-devices-one-bodyhttps://biotwin.ai/blog/six-connected-devices-one-bodyWearables are useful. They are also incomplete. When devices disagree about the same body, which one should you believe?Tue, 28 Apr 2026 00:00:00 GMTfounderfounder serieswearablesbiometricsHRVsleepGarminvalidationPierrick Hauguelhttps://biotwin.ai/blog/exercise-thresholds-recovery-and-overreachhttps://biotwin.ai/blog/exercise-thresholds-recovery-and-overreachEffort is not the same thing as capacity. The most dangerous number in performance is not the workout you completed. It is the debt you did not know you created.Mon, 27 Apr 2026 00:00:00 GMTfounderfounder seriesexercisetraining loadHRVperformanceIronmanrecoveryPierrick Hauguelhttps://biotwin.ai/blog/me-vs-me-your-biological-baselinehttps://biotwin.ai/blog/me-vs-me-your-biological-baselineThe most useful comparison in health may not be you versus everyone else. It may be you versus you. The Me vs. Me thesis behind every BioTwin score.Sun, 26 Apr 2026 00:00:00 GMTfounderfounder seriesBTIDindividual baselinemetabolomicspersonalized healthPierrick Hauguelhttps://biotwin.ai/blog/biological-age-is-a-trajectoryhttps://biotwin.ai/blog/biological-age-is-a-trajectoryBiological age is often presented as a verdict. It is also incomplete. A body is not a static number. It is a trajectory.Sat, 25 Apr 2026 00:00:00 GMTfounderfounder seriesbiological agelongevitytrajectoryVitolimetabolomicsPierrick Hauguelhttps://biotwin.ai/blog/from-personal-data-to-preventive-medicinehttps://biotwin.ai/blog/from-personal-data-to-preventive-medicineThe founder dataset is not the finish line. It is the stress test. How a single dense individual case becomes the architecture for population-scale preventive medicine.Fri, 24 Apr 2026 00:00:00 GMTfounderfounder seriespreventive medicineplatformwhite paperresearchtrajectoryPierrick Hauguelhttps://biotwin.ai/blog/publications/cancer-paperhttps://biotwin.ai/blog/publications/cancer-paperPreprint by Anctil, Hauguel, Rhéaume, Grobmyer, and Noel showing that untargeted metabolomics from a single dried blood spot detects breast cancer across 2,734 participants, with performance that is robust across six classifier families.Fri, 24 Apr 2026 00:00:00 GMTpublicationoncologybreast cancermetabolomicsdried blood spotspreprintNicolas Anctil, Pierrick Hauguel, Caroline Rhéaume, Stephen Grobmyer, Louis-Philippe Noelhttps://biotwin.ai/blog/publications/biometrics-paperhttps://biotwin.ai/blog/publications/biometrics-paperPreprint by Hauguel, Anctil, and Noel demonstrating that metabolomic profiles from dried blood spots are stable enough to identify individuals across 18,288 samples and 134 analytical batches.Sat, 11 Apr 2026 00:00:00 GMTpublicationbiometricsmetabolomicsdried blood spotspreprintPierrick Hauguel, Nicolas Anctil, Louis-Philippe Noelhttps://biotwin.ai/blog/publications/wearable-inter-device-agreementhttps://biotwin.ai/blog/publications/wearable-inter-device-agreementPreprint by Hauguel, Noel, and Anctil quantifying how poorly four consumer wearables agree with each other across an N-of-1 dataset spanning more than 2,400 days, and how much a harmonization layer can recover.Sun, 22 Mar 2026 00:00:00 GMTpublicationwearablesdigital phenotypinginter-device agreementlongitudinal monitoringpreprintPierrick Hauguel, Louis-Philippe Noel, Nicolas Anctilhttps://biotwin.ai/blog/virtual-twin-methodologyhttps://biotwin.ai/blog/virtual-twin-methodologyA comprehensive overview of BioTwin's virtual twin methodology, how multi-omics data, machine learning, and longitudinal tracking combine to create individualized health models.Sun, 15 Mar 2026 00:00:00 GMTfoundervirtual twinmethodologymetabolomicsmachine learningprecision medicineBioTwin Research Teamhttps://biotwin.ai/blog/metabolomics-preventive-medicinehttps://biotwin.ai/blog/metabolomics-preventive-medicineHow metabolomic profiling captures real-time biological state, and why it's essential for meaningful health prediction beyond genomics alone.Tue, 10 Mar 2026 00:00:00 GMTfoundermetabolomicspreventive medicinebiomarkersmulti-omicsprecision healthBioTwin Research Teamhttps://biotwin.ai/blog/longitudinal-health-trackinghttps://biotwin.ai/blog/longitudinal-health-trackingHow tracking biomarkers over time reveals health trajectories invisible to single-point assessments, and what this means for preventive care programs.Sun, 01 Mar 2026 00:00:00 GMTfounderlongitudinal datahealth trackingbiomarkersdigital healthpreventive careBioTwin Research Teamhttps://biotwin.ai/blog/publications/human-digital-twin-individual-profiling-dbshttps://biotwin.ai/blog/publications/human-digital-twin-individual-profiling-dbsPeer-reviewed open-access study (Digital Twin, 2024) by Fradin, Noel and colleagues, the foundational BioTwin work showing that untargeted metabolomics from dried blood spots can profile and identify individuals across 277 volunteers.Wed, 29 May 2024 00:00:00 GMTpublicationdigital twinmetabolomicsdried blood spotsprecision medicinepublishedManon Fradin, Louis-Philippe Noel, Gabriel Talbot-Lachance, Pierre Snell, Keven Voyer, Caroline Rheaume